My name is Kunio Nakamura.

I’m a post-doctoral fellow at the Brain Imaging Centre, Montreal Neurological Institute. My supervisors are Dr. D. Louis Collins and Dr. Douglas L. Arnold. My email is kunio.nakamura _at_ mcgill.ca.



Current Projects:

• Brain atrophy

• Sources of brain volume change

• Hydration status

• Simulation Studies

• Simulation of brain atrophy
• Simulation of focal multiple sclerosis lesions

• Cortical pathology in multiple sclerosis



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Publication Lists:


my google scholar page

Peer-reviewed Articles:

[7] Nakamura K, Guizard N, Fonov SV, Narayanan S, Collins DL, Arnold DL, Jacobian integration method increases the statistical power to measure gray matter atrophy in multiple sclerosis.

[6] Chen JT, Easley K, Schneider C, Nakamura K, Kidd GJ, Chang A, Staugaitis SM, Fox RJ, Fisher E, Arnold DL, Trapp BD, Clinically feasible MTR is sensitive to cortical demyelination in MS. Neurology 2013; Jan 15;80(3):246–52.

[5] Nakamura K, Fox R, Fisher E, CLADA: cortical longitudinal atrophy detection algorithm. NeuroImage. 2011; 54(1): 278–289.

[4] Rudick R, Lee J, Nakamura K, Fisher E, Gray matter atrophy correlates with MS disability progression measured with MSFC but not EDSS, Journal of Neurological Sciences. 2009; 106–111.

[3] Nakamura K and Fisher E, Segmentation of Brain Magnetic Resonance Images for Measurement of Gray Matter Atrophy in Multiple Sclerosis Patients, NeuroImage. 2009; 44(3): 769–776.

[2] Fisher E, Lee J, Nakamura K, Rudick RA, Gray Matter Atrophy in Multiple Sclerosis: A Longitudinal Study, Annals of Neurology 2008; 64(3): 255–265.

[1] Fisher E, Chang A, Fox RJ, Tkach JA, Svarovsky T, Nakamura K, Rudick RA, Trapp BD, Imaging correlates of axonal swelling in chronic multiple sclerosis brains. Annals of Neurology 2007; 62(3): 219–228.


Conference abstracts (oral/poster, international/national/local):

[22] Nakamura K, Guizard N, Narayanan S, Collins DL, Arnold DL, Evaluation of Brain Atrophy Measurement Methods: a simulated MRI study. 2013 endMS Conference. December 10–13, 2013. Saint-Sauveur, Quebec, Canada. (Accepted)

[21] Guizard N, Nakamura K, Coupé P, Arnold DL, Collins DL, Non-local MS MRI lesion inpainting method for image processing. 2013 endMS Conference. December 10–13, 2013. Saint-Sauveur, Quebec, Canada. (Accepted)

[20] Ghassemi R, Brown RA, Narayanan S, Nakamura K, Banwell B, Arnold DL, on behalf of the Canadian Pediatric Demyelinating Disease Study Group. Children with RRMS show less permanent T1 abnormality in new lesions compared adults with RRMS. European Committee for Treatment and Research in Multiple Sclerosis. Copenhagen Denmark. October 2–5, 2013.

[19] Nakamura K, Guizard N, Fonov VS, Narayanan S, Collins DL, Arnold DL, Pairwise Jacobian Integration Method to Measure Grey Matter Atrophy in Multiple Sclerosis. International Society for Magnetic Resonance in Medicine Workshop on Multiple Sclerosis as a Whole-Brain Disease. London, England, United Kingdom. June 26–28, 2013. (Oral Presentation)

[18] Nakamura K, Brown RA, Araujo D, Arnold DL, Effect of hydration level on brain tissue volumes. Neuroinflammation Training Program 8th Annual Symposium. Montreal, Quebec, Canada. June 6, 2013.

[17] Nakamura K, Narayanan S, Arnold DL, Longitudinal pre-processing decreases the required sample size for measurement of cortical atrophy in multi-centre MS clinical trials. European Committee for Treatment and Research in Multiple Sclerosis. Lyon France. October 10–13, 2012.

[16] Fisher E, Lee JC, Nakamura K, Jagodnik P, Rudick RA, Regional White Matter Tissue Damage Predicts Local Cortical Thinning in Multiple Sclerosis. American Academy of Neurology, New Orleans, Louisiana, USA. April 21–28, 2012.

[15] Chen JT, Schneider C, Nakamura K, Easley K, Kidd GJ, Chang A, Staugaitis SM, Fox RJ, Fisher E, Arnold DL, Trapp PD, Image-processing of high-quality MRI with histopathological validation for detection of cortical demyelination in MS brains. European Committee for Treatment and Research in Multiple Sclerosis, Amsterdam, the Netherlands. October 19–22, 2011.

[14] Chen JT, Schneider C, Nakamura K, Easley K, Kidd GJ, Chang A, Staugaitis SM, Fox RJ, Fisher E, Arnold DL, Trapp BD, Image-processing of high-quality MRI to detect cortical demyelination in MS brains. Neurological Institute Research, Cleveland Clinic Foundation, Cleveland, Ohio, USA. May 26, 2011.

[13] Nakamura K, Fox RJ, Fisher E, Comparison of Longitudinal and Cross-sectional Cortical Thickness Measurements. International Society for Magnetic Resonance in Medicine, Montreal, Quebec, Canada. May 7–13, 2011.

[12] Fisher E, Nakamura K, Lee JC, Rudick R, Cortical Thinning and Disability Progression in Multiple Sclerosis. American Academy of Neurology, Honolulu, USA. April 9–16, 2011.

[11] Fisher E, Nakamura K, Pace A, Lee JC, Foulds P, Rudick RA, Associations between grey matter atrophy and disability in a placebo-controlled trial of interferon beta-1a in relapsing-remitting multiple sclerosis. European Committee for Treatment and Research in Multiple Sclerosis 2010, Gothenburg, Sweden, 13–16 October 2010

[10] Chen JT, Schneider C, Nakamura K, Easley K, Kidd GJ, Stagnates SM, Fox RJ, Fisher E, Arnold DL, Trapp BD, Validation of MRI-based measurements of subpial cortical demyelination in an MS brain. European Committee for Treatment and Research in Multiple Sclerosis 2010, Gothenburg, Sweden, 13–16 October 2010.

[9] Chen JT, Schneider C, Nakamura K, Kidd GJ, Chang A, Staugaitis SM, Fox RJ, Fisher E, Arnold DL, Trapp DB, Validation of Magnetic Resonance Imaging-Based Measurements of Subpial Cortical Demyelination in a Multiple Sclerosis Brain. Neurological Institute Research, Cleveland Clinic Foundation, Cleveland, Ohio USA. May 27, 2010.

[8] Nakamura K, Lee J, Foulds P, Rudick RA, Fisher E, Effect of intramuscular interferon beta-1a on gray matter atrophy in relapsing-remitting multiple sclerosis. American Academy of Neurology 2010, Toronto, Ontario, Canada.

[7] Fisher E, Thomas S, Moll N, Rietsch A, Nakamura K, Fox R, Ransohoff R, Pathologic Correlates of MRI-Detected Diffuse Tissue Damage in MS Brains. World Congress on Treatment and Research in Multiple Sclerosis 2008, Montreal, Quebec, Canada. September 17–20, 2008.

[6] Nakamura K, Rudick RA, Fisher E, Longitudinal Cortical Thickness Measurement in Multiple Sclerosis Patients. World Congress on Treatment and Research in Multiple Sclerosis 2008, Montreal, Quebec, Canada. September 17–20, 2008.

[5] Fisher E, Lee J, Nakamura K, Rudick RA, A 4-Year Longitudinal Study of Gray Matter Atrophy in Multiple Sclerosis Patients. American Academy of Neurology, April 12–18,2008, Chicago, Illinois, USA.

[4] Nakamura K, Rudick RA, Fisher E, Longitudinal Cortical Gray Matter Atrophy Detection Algorithm Using Geometric Active Contours: a validation study. International Society for Magnetic Resonance in Medicine, Montreal 2008. Toronto, Ontario, Canada.

[3] Fisher E, Chang A, Nakamura K, Rudick RA, Trapp BD, MRI Correlates of Hippocampal Demyelination in Multiple Sclerosis Brains. International Society for Magnetic Resonance in Medicine, May 3–9, 2008. Toronto, Ontario, Canada.

[2] Nakamura K, Lee J, Rudick RA, Fisher E, Validation of gray matter atrophy measurements in multiple sclerosis patients. Biomedical Graduate Student Symposium, Case Western Reserve University, Cleveland, Ohio, USA. May 17, 2007.

[1] Nakamura K and Fisher E, Automated Segmentation of Cortical Gray Matter in Brain Magnetic Resonance Images. Research ShowCASE, Case Western Reserve University, Cleveland, Ohio, USA. April 2, 2004.