Jacqueline T. Chen, PhD

chen@mrs.mni.mcgill.ca

Research Assistant
McGill University
Montreal Neurological Institute
Magnetic Resonance Spectroscopy Unit
Montreal, QC

Post-Doctoral Fellow
Lerner Research Institute
Department of Neurosciences
Cleveland, OH

*
Bachelors of Science (1995), Joint Major Physics-Physiology, McGill University, Montreal, Canada
*
Masters of Engineering (2000), Biomedical Engineering, McGill University, Montreal, Canada
Supervised by Dr. RE Kearney and Dr. DL Arnold
Topic: A fully automated system for analyzing phosphorus magnetic resonance spectroscopy data obtained from skeletal muscle in vivo

*

*
Doctorate (2008), Biomedical Engineering, McGill University, Montreal, Canada
Supervised by Dr. DL Arnold and Dr. DL Collins
Topic: Image-processing of MRI for measuring brain injury, repair and degeneration in patients with multiple sclerosis

*

Full-paper and short-report publications (Peer-reviewed):

Chen JT, Collins DL, Atkins HL, Freedman MS, Arnold DL: MTR evolution with demyelination and remyelination in MS lesions, Annals of Neurology, 63(2): 254-62, 2008.
*
Kezele IB, Chen JT, Arnold DL, Collins DL: The relation of focal white matter signal abnormality and focal volume loss in multiple sclerosis, Multiple Sclerosis, 13(6): 809-13, 2007.
*
Chen JT, Kuhlmann T, Jansen GH, Collins DL, Atkins HL, Freedman MS, O'Connor PW, Arnold DL: Voxel-based analysis of the evolution of magnetization transfer ratio to quantify remyelination & demyelination with histopathological validation in a multiple sclerosis lesion, Neuroimage, 36(4):1152-8, 2007.
*
Openshaw H, Atkins HL, Chen JT, de Bittencourt PRM, Griffith LM, Kerr DA, Khoury SA, Muraro PA, Nash RA, Saccardi R: Multiple sclerosis conference synopsis and discussion: cellular therapy for treatment of autoimmune diseases (October 2005), Multiple Sclerosis, 12: 824-5, 2006.
*
Chen JT, Collins DL, Atkins HL, Freedman MS, Galal A, Arnold DL, and the Canadian MS/BMT Study Group: Brain atrophy after immunoablation and stem cell transplantation in multiple sclerosis, Neurology, 66(12): 1935-7, 2006.
*
Chen JT, Collins DL, Freedman MS, Atkins HL, the Canadian MS/BMT Study Group, Arnold DL: Local magnetization transfer ratio signal inhomogeneity is related to subsequent change in MTR in lesion and normal-appearing white-matter of multiple sclerosis patients, Neuroimage, 25(4): 1272-78, 2005.
*
Chen JT, Narayanan S, Collins DL, Smith SM, Matthews PM, Arnold DL: Relating neocortical pathology to disability progression in multiple sclerosis using MRI, Neuroimage, 23(3): 1168-75, 2004.
*
Smith SM, Zhang Y, Jenkinson M, Chen JT, Matthews PM, Federico A, De Stefano N: Accurate, Robust, and Automated Longitudinal and Cross-Sectional Brain Change Analysis, Neuroimage, 17(1): 479-89, 2002.
*
Chen JT, Taivassalo T, Argov Z, Arnold DL: Modeling in vivo recovery of intracellular pH in muscle to provide a novel index of proton handling: Application to the diagnosis of mitochondrial myopathy, Magnetic Resonance in Medicine, 46:870-878. November 2001.
*
Taivassalo T, Shoubridge EA, Chen JT, Kennaway NG, DiMauro S, Arnold DL, Haller RG: Aerobic conditioning in patients with mitochondrial myopathies: Physiological, biochemical, and genetic effects, Annals of Neurology, 50:133-141, August 2001.
*
Marrie RA, Shoubridge EA, Antel JP, Arnold DL, Chen JT, Andermann E, Andermann F: Unusual imaging findings in progressive myoclonus epilepsy, Epilepsia, 42:430-432, March 2001.
*
Tartaglia MC, Chen JT, Caramanos Z, Taivassalo T, Arnold DL, Argov Z: Muscle Phosphorus MRS Oxidative Indices Correlate with Physical Activity, Muscle & Nerve, 23:175-181, February 2000.
*
Taivassalo T, De Stefano N, Chen JT, Karpati G, Arnold DL, Argov Z: Short-Term Aerobic Training Response in Chronic Myopathies, Muscle & Nerve, 22:1239-43, September 1999.
*
Chen JT, Argov Z, Kearney RE, Arnold DL: Fitting Cytosolic ADP Recovery After Exercise with a Step Response Function, Magnetic Resonance in Medicine, 41:926-32, May 1999.
*
Taivassalo T, De Stefano N, Argov Z, Matthews PM, Chen JT, Genge A, Karpati G, Arnold DL: Effects of aerobic training in patients with mitochondrial myopathies, Neurology, 50(4):1055-60, April 1998.
*
Argov Z, De Stefano N, Taivassalo T, Chen JT, Karpati G, Arnold DL: Abnormal oxidative metabolism in exercise intolerance of undetermined origin, Neuromuscular Disorders, 7(2):99-104, March 1997.
*

Other publications:

Arnold DL, Chen J: Measuring injury and repair of myelin and neurons in multiple sclerosis, Ernst Schering Res Found Workshop, 2005; (53): 173-86.

Selected Abstracts (Peer-reviewed):

Chen JT, Collins DL, Derakhshan M, Arnold DL: Quantifying MRI with increased specificity for MS pathology: A longitudinal method for obtaining whole-brain metrics of 3D maps derived from non-conventional MRI, Proc. Intl. Soc. Mag. Reson. Med. 16, 2136, 2008.
*
Chen JT, Freedman MS, Atkins HL, Arnold DL: A Controlled Study of the Acute Effect of Immunoablation and Autologous Hematopoietic Stem Cell Transplantation on Changes in Brain Volume, Axonal Integrity, Myelin, and Parenchymal Water, in Multiple Sclerosis, Neurology, 68 (12 Suppl 1): A332, 2007.
*
Chen JT, Collins DL, Freedman MS, Atkins HL, Arnold DL: Detection of subpial cortical demyelinating lesions in multiple sclerosis in vivo: methodology and evaluation in normal subjects and patients with MS, Multiple Sclerosis, 12(Suppl. 1), S181, September 2006.
*
Chen JT, Collins DL, Atkins HL, Freedman MS, Arnold DL: Detection of subpial cortical demyelinating lesions in multiple sclerosis in vivo, Proceedings of the International Society for Magnetic Resonance in Medicine, Fourteenth Scientific Meeting and Exhibition, May 2006.
*
Chen JT, Freedman MS, Atkins HL, Narayanan S, Arnold DL: Immunoablation and autologous hematopoietic stem cell transplantation may enhance remyelination in acute multiple sclerosis lesions, Neurology, 66 (5 Suppl 2): A98, 2006.
*
Chen JT, Kuhlmann T, Jansen GH, Collins DL, Freedman MS, Atkins HL, Bar-Or A, Arnold DL, and the Canadian MS BMT Study Group: Histopathological confirmation of voxel-based analysis of in vivo magnetization transfer ratio images to assess remyelination and demyelination following acute focal demyelination in multiple sclerosis, Multiple Sclerosis, 11(Suppl 1):S139, 2005.
*
Chen JT, Narayanan S, Collins DL, Freedman MS, Atkins HL, the Canadian MS BMT Study Group, and Arnold DL: All enhancing voxels are not equal: quantifying destruction and repair within gadolinium-enhancing lesions in multiple sclerosis. Proceedings of the International Society for Magnetic Resonance in Medicine, Thirteenth Scientific Meeting and Exhibition, p. 319, May 2005.
*
Chen JT, Collins DL, Freedman MS, Atkins HL, the Canadian MS BMT Study Group, and Arnold DL: Evidence for acute brain "pseudo-atrophy" after treating MS with immunoablation followed by autologous stem cell transplantation, Neurology, 64 (Suppl 1), A393, 2005.
*
Chen JT, Narayanan S, Arnold DL, Freedman MS, Atkins HL, and the Canadian MS BMT Study Group: The effect of immunoablation with autologous stem cell transplantation therapy on dynamic changes of magnetization transfer ratio in multiple sclerosis patients, Multiple Sclerosis, 10(Suppl 2), S271, 2004.
*
Chen JT, Collins DL, Freedman MS, Atkins HL, Arnold DL: Measuring the potential for remyelination and demyelination in multiple sclerosis lesions, Proceedings of the International Society for Magnetic Resonance in Medicine, Twelfth Scientific Meeting, May 2004.
*
Chen JT, Arnold DL, Freedman MS, Atkins HL, and the Canadian MS BMT Study Group: The Impact of Immunoablation with Autologous Stem Cell Transplant on Lesion Remyelination and Demyelination in Aggressive Multiple Sclerosis, Neurology, 62(7, Suppl 5), A351, 2004.
*
Chen JT, Narayanan S, Collins DL, Smith SM, Matthews PM, Arnold DL: Characterizing Cortical Grey Matter in Multiple Sclerosis by MRI: relating cGM changes to disease course, Proceedings of the International Society for Magnetic Resonance in Medicine, Eleventh Scientific Meeting and Exhibition, p. 271, May 2003.
*
Chen JT, Smith SM, Arnold DL, Matthews PM: Quantification of Change in Cortical Grey Matter Thickness, Proceedings of the International Society for Magnetic Resonance in Medicine, Tenth Scientific Meeting and Exhibition, 1:351, May 2002.
*
Chen JT, Matthews PM, Arnold DL, Smith SM: Relating the Regional Effects of Brain Atrophy in Multiple Sclerosis: The difference in brain atrophy progression in Relapsing-Remitting and Secondary Progressive, Proceedings of the International Society for Magnetic Resonance in Medicine, Ninth Scientific Meeting and Exhibition, 1:265, April 2001.
*
Chen JT, Arnold DL: Modeling recovery of pHi in muscle in vivo to provide a novel index of proton handling in mitochondrial myopathy, Proceedings of the International Society for Magnetic Resonance in Medicine, Eighth Scientific Meeting and Exhibition, 1:423, April 2000.
*
Chen JT, Tartaglia MC, Taivassalo T, Kearney RE, Arnold DL: Using Nearest-Neighbour Analysis to Evaluate 31P-MRS Recovery Indices Relative to Conditioning and Metabolic State at Rest and End of Exercise, Proceedings of the International Society for Magnetic Resonance in Medicine, Seventh Scientific Meeting and Exhibition, 3:1594, May 1999.
*
Chen JT, Argov Z, Kearney RE, Arnold DL: Using a Step Response Function to Fit Cytosolic ADP Recovery After Exercise, Proceedings of the International Society for Magnetic Resonance in Medicine, Sixth Scientific Meeting and Exhibition, 1:31, April 1998. ssh_xterm