Publications

Alpha-methyltryptophan/5-HT synthesis
1. Image generation of serotonin synthesis rates using alpha-methyltryptophan and PET.
   Okazawa H and Diksic M. J Comput Assist Tomogr 1998; 22:777-85.
2. Validation of a less-invasive method for measurement of serotonin synthesis rate with alpha-[11C]methyl-tryptophan
   Nishizawa S, Leyton M, Okazawa H, Benkelfat C, Mzengeza S, Diksic M. J Cereb Blood Flow Metab 1998;18:1121-9.

   Activation Studies

3. Cortical activation by monaural speech sound stimulation demonstrated by positron emission tomography.
   Hirano S, Naito Y, Okazawa H, Kojima H, Honjo I, Ishizu K, Yenokura Y, Nagahama Y, Fukuyama H, Konishi J. Exp Brain Res 1997; 113:75-80.
4. Cortical processing mechanism for vocalization with auditory verbal feedback.
   Hirano S, Kojima H, Naito Y, Honjo I, Kamoto Y, Okazawa H, Ishizu K, Yonekura Y, Nagahama Y, Fukuyama H, Konishi J. Neuroreport 1997 ;8:2379-82.
5. The role of the temporal coding system in the auditory cortex on speech recognition.
   Kojima H, Hirano S, Shoji K, Naito Y, Honjo I, Kamoto Y, Okazawa H, Ishizu K, Yonekura Y, Nagahama Y, Fukuyama H, Konishi J. Neuroreport 1997 ;8:2395-98.
6. Central auditory processing of speech in cochlear implant users demonstrated by positron emission tomography.
   Naito Y, Hirano S, Okazawa H, Takahashi H, Ishizu K, Fujiki N, Shiomi Y, Kawano M, Yonekura Y, Honjo I. Advances in Oto Rhino Laryngology 1997;52:19-23.
7. Sound-induced activation of auditory cortices in cochlear implant users with post- and prelingual deafness demonstrated by positron emission tomography.
   Naito Y, Hirano S, Honjo I, Okazawa H, Ishizu K, Takahashi H, Fujiki N, Shiomi Y, Yonekura Y, Konishi J. Acta Oto Laryngologica 1997;117:490-96.
8. Cortical speech processing mechanisms while vocalizing visually presented languages.
   Hirano S, Kojima H, Naito Y, Honjo I, Kamoto Y, Okazawa H, Ishizu K, Yonekura Y, Nagahama Y, Fukuyama H, Konishi J. Neuroreport 1996 ;8:363-67.
9. Cochlear implant efficiency in pre- and postlingually deaf subjects - A study with (H2O)-O-15 and PET.
   Okazawa H, Naito Y, Yonekura Y, Sadato N, Hirano S, Nishizawa S, Magata Y, Ishizu K, Tamaki N, Honjo I, Konishi J. Brain 1996; 119:1297-1306.
10. Cortical activation with sound stimulation in cochlear implant users demonstrated by positron emission tomography.
    Naito Y, Okazawa H, Honjo I, Hirano S, Takahashi H, Shiomi Y, Hoji W, Kawano M, Ishizu K, Yonekura Y. Cognitive Brain Res 1995;2:207-14.
11. Cortical activation during sound stimulation in cochlear implant users demonstrated by positron emission tomography.
    Naito Y, Okazawa H, Honjo I, Takahashi H, Kawano M, Ishizu K, Yonekura Y. Annals of Otology, Rhinology, & Laryngology (Supplement) 1995;166:60-4.
12. Delayed data acquisition for optimal PET activation studies with oxygen-15-water in cerebral arteriovenous malformation.
    Okazawa H, Yonekura Y, Sadato N, Lyshkow H, Nishizawa S, Asato R, Magata Y, Ishizu K, Tamaki N, Konishi J, Kikuchi H. J Nucl Med 1995; 36: 2149-53.
13. Optimal dose of injection in activation study with O-15 water and PET.
    Sadato N, Yonekura Y, Magata Y, Nishizawa S, Ishizu K, Okazawa H, Tsuchida T, Tanaka F, Tamaki N, Sasayama S, Shibasaki H, Konishi J. Ann Nucl Med 1994 ;8:239-43.

    Cu-PTSM and Cu-HSA-DTS

14. Selective cerebral hematocrit decrease in the centrum semiovale after carotid artery occlusion: A PET study.
    Yamauchi H, Fukuyama H, Nagahama Y, Katsumi Y, Hayashi T, Okazawa H, Yonekura Y. J Cereb Blood Flow Metab 1999;19:109-114.
15. Cerebral hematocrit decreases with hemodynamic compromise in carotid artery occlusion: A PET study.
    Yamauchi H, Fukuyama H, Nagahama Y, Katsumi Y, Okazawa H. Stroke 1998; 29:98-103.
16. Measurement of regional cerebral blood flow with copper-62-PTSM and a three-compartment model.
    Okazawa H, Yonekura Y, Fujibayashi Y, Mukai T, Nishizawa S, Magata Y, Ishizu K, Tamaki N, Konishi J. J Nucl Med 1996; 37: 1089-93.
17. Measurement of regional cerebral plasma pool and hematocrit with copper-62-labeled HSA-DTS.
    Okazawa H, Yonekura Y, Fujibayashi Y, Yamauchi H, Ishizu K, Nishizawa S, Magata Y, Tamaki N, Fukuyama H, Yokoyama A, Konishi J. J Nucl Med 1996; 37: 1080-85.
18. Generator-produced copper-62-ptsm as a myocardial pet perfusion tracer compared with nitrogen-13-ammonia.
    Tadamura E, Tamaki N, Okazawa H, Fujibayashi Y, Kudoh T, Yonekura Y, Magata Y, Nohara R, Sasayama S, Konishi J. J Nucl Med 1996 ;37:729-35.
19. Clinical application of 62Zn/62Cu positron generator: Perfusion and plasma pool images in normal subjects.
    Okazawa H, Fujibayashi Y, Yonekura Y, Tamaki N, Nishizawa S, Magata Y, Ishizu K, Tsuchida T, Sadato N, Konishi J, Yokoyama A, Iwata R, Ido T. Ann Nucl Med 1995;9:81-7.
20. Cu-pyruvaldehyde-bis(N4-methylthiosemicarbazone) (Cu-PTSM), a metal complex with selective NADH-dependent reduction by complex I in brain mitochondria: a potential radiopharmaceutical for mitochondria-functional imaging with positron emission tomography (PET).
    Taniuchi H, Fujibayashi Y, Okazawa H, Yonekura Y, Konishi J, Yokoyama A. Biol Pharm Bull 1995;18:1126-29.
21. Clinical application and quantitative evaluation of generator-produced copper-62-PTSM as a brain perfusion tracer for PET.
    Okazawa H, Yonekura Y, Fujibayashi Y, Nishizawa S, Magata Y, Ishizu K, Tanaka F, Tsuchida T, Tamaki N, Konishi J. J Nucl Med 1994; 35: 1910-15.

    FDG

22. [F-18]-Fluorodeoxyglucose-positron emission tomography findings in preterm infants with severe periventricular leukomalacia and hypsarrhythmia.
    Higuchi Y, Maihara T, Hattori H, Furusho K, Okazawa H, Ishizu K, Yonekura Y. Eur J Pediatrics 1997;156:236-238.
23. Effects of hyperglycemia on FDG uptake in human brain and glioma.
    Ishizu K, Nishizawa S, Yonekura Y, Sadato N, Magata Y, Tamaki N, Tsuchida T, Okazawa H, Miyatake S, Ishikawa M, Kikuchi H, Konishi J. J Nucl Med 1994;35:1104-9.
24. Enhanced detection of brain tumors by [18F]fluorodeoxyglucose PET with glucose loading.
    Ishizu K, Sadato N, Yonekura Y, Nishizawa S, Magata Y, Tamaki N, Tsuchida T, Okazawa H, Tanaka F, Miyatake S, Ishikawa M, Kikuchi H, Konishi J. J Comput Assist Tomogr 1994;18:12-5.
25. Enhanced detection of brain tumors with glucose loading in FDG-PET studies: quantitative evaluation by fractional uptake.
    Ishizu K, Sadato N, Yonekura Y, Nishizawa S, Magata Y, Tsuchida T, Okazawa H, Tanaka F, Tamaki N, Miyatake S, Ishikawa M, Kikuchi H, Konishi J. (In) Quantification of Brain Function: Tracer Kinetics and Image Analysis in Brain PET, Uemura K, Lassen NA, Jones T, Kanno I (eds), Elsevier Science Publishers, Amsterdam, 179-182, 1993.

    SPECT

26. Presurgical identification of epileptic foci with iodine-123 iomazenil spet - comparison with brain perfusion spet and fdg pet.
    Tanaka F, Yonekura Y, Ikeda A, Terada T, Mikuni N, Nishizawa S, Ishizu K, Okazawa H, Hattori N, Shibasaki H, Konishi J, Onishi Y. Eur J Nucl Med 1997 ;24:27-34.
27. Noninvasive quantification of iodine-123-iomazenil SPECT.
    Onishi Y, Yonekura Y, Nishizawa S, Tanaka F, Okazawa H, Ishizu K, Fujita T, Konishi J, Mukai T. J Nucl Med 1996 ;37:374-78.
28. Delayed image of iodine-123 iomazenil as a relative map of benzodiazepine receptor binding - the optimal scan time.
    Onishi Y, Yonekura Y, Tanaka F, Nishizawa S, Okazawa H, Ishizu K, Fujita T, Konishi J, Mukai T. Eur J Nucl Med 1996 ;23:1491-97.
29. One-day protocol for cerebral perfusion reserve with acetazolamide.
    Hattori N, Yonekura Y, Tanaka F, Fujita T, Wang JY, Ishizu I, Okazawa H, Tamaki N, Konishi J. J Nucl Med 1996;37:2057-61.
30. Extraction and retention of technetium-99mTc-ECD in human brain - dynamic spect and oxygen-15-water pet studies.
    Ishizu K, Yonekura Y, Magata Y, Okazawa H, Fukuyama H, Tanaka F, Hattori N, Kitano H, Fujita T, Tamaki N, Konishi J. J Nucl Med 1996;37:1600-4.
31. Simplified quantification of regional cerebral blood flow with 99mTc-ECD SPECT and continuous arterial blood sampling.
    Yonekura Y, Ishizu K, Okazawa H, Tanaka F, Hattori N, Sadato N, Tsuchida T, Nishizawa S, Tamaki N, Nagamine T, Konishi J, Shibasaki H. Ann Nucl Med 1996 ;10:177-83.
32. Simple quantification of benzodiazepine receptor binding and ligand transport using iodine-123-iomazenil and two SPECT scans.
    Onishi Y, Yonekura Y, Mukai T, Nishizawa S, Tanaka F, Okazawa H, Ishizu K, Fujita T, Sibasaki H, Konishi J. J Nucl Med 1995;36:1201-10.
33. Evaluation of a double-injection method for sequential measurement of cerebral blood flow with iodine-123-iodoamphetamine.
    Nishizawa S, Yonekura Y, Tanaka F, Fujita T, Tsuchimochi S, Ishizu K, Okazawa H, Tamaki N, Konishi J. J Nucl Med 1995;36:1339-45.
34. Changes in cerebral blood flow induced by balloon test occlusion of the internal carotid artery under hypotension.
    Tanaka F, Nishizawa S, Yonekura Y, Sadato N, Ishizu K, Okazawa H, Tamaki N, Nakahara I, Taki W, Konishi J. Eur J Nucl Med 1995 ;22:1268-73.
35. Limited value of interictal brain perfusion SPECT for detection of epileptic foci: High resolution SPECT studies in comparison with FDG-PET.
    Nagata T, Tanaka F, Yonekura Y, Ikeda A, Nishizawa S, Ishizu K, Okazawa H, Terada K, Mikuni N, Yamamoto I, et al. Ann Nucl Med 1995;9:59-63.

    Japanese Journals

36. Parametric images of central-type benzodiazepine receptor binding and ligand transport by two SPECT scans of 123I-iomazenil: relative quantification without blood data.
    Onishi Y, Yonekura Y, Tanaka F, Nishizawa S, Okazawa H, Ishizu K, Fujita T, Konishi J, Mukai T. Kaku Igaku (Jpn J Nucl Med) 1996;33:953-963.
37. Phase 1 clinical study of 123I-iomazenil: a new probe to evaluate central-type benzodiazepine receptor with SPECT.
    Yonekura Y, Nishizawa S, Tanaka F, Ishizu K, Okazawa H, Fujita T, Konishi J, Torizuka K. Kaku Igaku (Jpn J Nucl Med) 1995;32:87-97.
38. Positron emission tomography for assessing patients with coronary artery disease. Tamaki N, Tadamura E, Kawamoto M, Torizuka T, Inokuma T, Okazawa H, Tanaka F, Nishizawa S, Ishizu K, Magata Y, Yonekura Y, Konishi J. Japanese Journal of Clinical Radiology 1993;38:1673-1681.
39. Therapy of malignant pheochromocytoma using I-131 metaiodobenzylguanidine--report of a case.
    Okazawa H, Endo K, Saga T, Watanabe Y, Nakai T, Kasagi K, Konishi J, Abe M, Goto K, Nakao K