If the data was acquired in the 'usual' MNI way: x increases from px left to right, 20 slices, 8 mm step size z increases from px inferior to superior, 256 slices, -1 mm step size y increases from px posterior to anterior, 256 slices, -1 mm step size Then for each T2/PD volume run mincreshape: mincreshape -dimrange echo_time=0 subject_file_run_number_etc.mnc subject_file_run_number_pd.mnc mincreshape -dimrange echo_time=1 subject_file_run_number_etc.mnc subject_file_run_number_t2.mnc After the interleaved volumes have been separated, create a {pd|t2} volume with: concat_mri subject_file_*_{pd|t2}.mnc subject_file_{pd|t2}.mnc