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Three Dimensional Anatomical Atlas of the Human Brain

This is a three dimensional anatomical atlas of 1mm resolution in Talairach stereotaxic space. Manual segementation of an MR image acquired from an adult male human subject defined bilateral boundaries of 48 structures in the grey matter, white matter and cerebrospinal fluid. 27 cortical and 21 subcortical or extra-cortical structures were classified using a standardized nomenclature based on a specific hierarchiacal scheme.

 The objective of this project was to produce a completely space-filling atlas of a single MRI volume, where every voxel could be identified as part of brain or extra-brain structure. This atlas would serve as a template model for automatic segmentation of other MRI volumes and in the creation of a three dimensional probabalistic atlas of the human brain.

The creation of this atlas was inspired by a proposal put forth by the International Consortium of Brain Mapping (ICBM). The specific goal of the ICBM project is the development of a population-based digital probabilistic atlas of the human brain with a reference system in stereotaxic space. In order to produce such an atlas, a starting template was needed. Other than the advantage of being a teaching tool for normal anatomy, the probabilistic atlas may also be used for the localization of activation sites in functional studies and as a standard against which pathological brains can be analyzed.

Below are some images from this atlas: