Mark Wolforth's Home Page
Welcome to Mark Wolforth's Home Page
Short (hopefully descriptive) Blurb
Mark Wolforth (hey, that's me) is a Master's student in BioMedical Engineering at McGill University in Montreal, and is
studying at the McConnell Brain
Imaging Centre at the Montreal Neurological Institute. He
finished his B.Eng. (Electrical) at McGill in 1994.
His research interests are detailed below....
Here are some volume rendered images (from MR data) that vaguely
represent what I look like (although I doubt that you would recognize
me on the street from these)...
Click here for a peek inside
Sleep deprivation. No, that's only a sideline caused by my research
into functional MRI (fMRI), which allows researchers to "see" which
parts of the brain are active during tasks, completely non-invasively.
This is in contrast to other well-established functional mapping
methods such as PET, which are invasive (eg. PET requires the
injection of a radioactive tracer, and sometimes the taking of blood
Basically, here's the current thinking. We know from PET that the
flow of blood to a region of the brain increases when that region
becomes active. However, the amount of oxygen being consumed by the
region does not increase proportionately, and this creates a change in
the ratio of oxyhemoglobin to deoxyhemoglobin. Since oxyhemoglobin
and deoxyhemoglobin have different magnetic properties (one is
paramagnetic, while the other is diamagnetic), this ratio change
causes a corresponding disturbance in the magnetic field. This small
change in the field shows up as a small signal change in the final
As you might imagine, the resulting signal is very small, and is
hidden in a sea of physiological noise. My research involves the
extraction and quantification of the signal, and the application of
statistical methods developed for PET to this new modality.
Here are some documents that I have prepared for your viewing
pleasure. For people outside the MNI, these documents probably are of
very little interest to you, unless you are a user of EMMA.
- MATLAB Help Page This is the
development area for MATLAB help. The pages presented here are not
guaranteed to be in a working state. For the production version,
please consult the official MATLAB Help
- Blood Lab Documentation This is the
documentation for the blood lab computer.
- Software Map of my
endeavors at the MNI.
- Slide Maker FAQ, for those of you
interested in making slides for presentations.