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Triple-Weighted Integration Method

In order to model the complete two-compartment system, we must be able to solve equation (4). In section 2.2, we solved the equation by multiplying by two different weights and then dividing, and we can take a similar approach with the full two-compartment equation. We can weight equation (4) with three different weights and then integrate:

By multiplying equation (7) by and equation (9) by , and then subtracting the two, we may eliminate the term. A similar operation can be performed on equation (8) and equation (9). This leaves two equations that do not contain . They may then be divided to produce:

The term cancels out of both the numerator and denominator of equation (10), leaving an equation that only involves . As with the equation in section 2.2, this is very difficult to solve for . Therefore, a look-up table was again used. Once the table matching values of with values of the right hand side of equation (10) has been created, we may evaluate through simple lookup. With the data computed, finding is simply a matter of evaluating either the numerator or denominator of equation (10) without cancelling . With both and known, we may find by evaluating equation (4).


wolforth@pet.mni.mcgill.ca