Pathological Cortical Development

Risks: non-specific factors associated with fetal environmental exposures (e.g., prenatal maternal nutritional deficiency, winter birth, urban birth, maternal influenza, and birth & pregnancy complications;
Twin dermatoglyphic data also point to 2nd trimester event;
Antecedents: delayed neuromotor & language development, emotional, behavioural & cognitive abnormalities in childhood & adolescence;
“two-hit”hypothesis: genes + environment (early-environment genes late-environment disorder)

Risks: non-specific factors associated with fetal environmental exposures (e.g., prenatal maternal nutritional deficiency, winter birth, urban birth, maternal influenza, and birth & pregnancy complications;