Pathological Cortical Development

• Histopathological studies of schizophrenia:

  • changes in the cytoarchitectonic organization,
  • lower cellular concentration and counts,
  • smaller somal sizes,
  • reduced synaptic density,
  • and reductions in laminar thickness and total cortical thickness in a number of brain areas

• Findings in: Brodmann areas 9 (DPFC), 10, 17, 32 and 46, anterior cingulate cortex (ACC), the superior temporal gyrus, the Heschl's gyrus, and the entorhinal cortex