Research
Human epileptogenesis is a complex process, and its anatomical and functional basis is poorly understood. We believe that MRI techniques advance our understanding of the basic mechanisms of epilepsy.We have pioneered a series of novel computer-based methods to improve the detection of subtle epileptogenic lesions that are not visible on conventional MRI.
Particular emphasis is placed on temporal lobe epilepsy, epilepsy related to malformations of cortical development and idiopathic generalized epilepsy.
To assess brain pathology in various forms of epilepsy, we apply several advanced image acquisition techniques such as high-field structural imaging, T2-relaxometry, diffusion tensor imaging, and functional MRI. We also apply surface-based morphometry, texture analysis, volumetry, voxel-based morphometry, shape analysis, and morphometric correlation analysis.
We have the following main areas of research:
Characterization of structural substrate of epilepsy
High resolution T1 and T2 MRI in a patient with right paradoxical TLE show subtle signal changes in the right hippocampus
Modeling and automated detection of epileptogenic lesions
Modeling of focal cortical displasia through different MRI-based feature maps.
(Bernasconi et al. 2001, Annals of Neurology)
Assessment of abnormalities distant to the epileptic focus
Basal temporal lobe sulcal morphology. AM = amygdala, HH = hippocampal head, HB = hippocampal body, HT = hippocampal tail.
(Kim et al. 2001, Neurology)
Evaluation of disease progression
Volume decrease in the hippocampus of TLE patients over time.
(Bernasconi et al. 2005, Neurology)
Structural networks
Mapping of left entorhinal cortex (EC) connectivity using cortical thickness correlations.
(Bernhardt et al. 2008, NeuroImage)
Functional networks
Hand activation in double-cortex syndrome mapped through functional MRI.
(Jirsch et al. 2005, Human Brain Mapping)