Samson Antel, Ph.D.
MR Spectroscopy Unit, Montreal Neurological Institute
3801 University St.
Montreal, QC, Canada H3A 2B4

Phone: (514)-398-8524 Fax: (514)-398-2975
samson@mrs.mni.mcgill.ca

Personal Information:

Date of Birth: October 28, 1972
Citizenship: U.S. and Canadian

Education:

2003: Ph.D.
Biomedical Engineering
 McGill University & Montreal Neurological Institute
Researched the application of texture analysis methods to MRI to facilitate detection of lesions associated with focal cortical dysplasia, an epileptic disorder. Also studied the use of volumetric MRI and MR spectroscopy to predict surgical outcome in temporal lobe epilepsy patients.
1996: M.Sc.
Biomedical Engineering
 Rensselaer Polytechnic Institute (Troy, NY).
Studied the assessment of brain tumors and HIV infection stage via in vivo MR spectroscopy.
1994: B.Sc.
Mathematics
 McGill University

Work Experience:

June 2003- present: Faculty Lecturer/Research Associate, Magnetic Resonance Spectroscopy Unit, Montreal Neurological Institute.
Managing the clinical trial MRI analysis program.
Nov. 2002- present: Research Associate, Neuroimaging of Epilepsy Laboratory, Montreal Neurological Institute.
Responsibilities include the development and application of advanced image processing techniques to the study of various epileptic disorders.
Sept. 1996-March 2003: Research Assistant, Magnetic Resonance Spectroscopy Unit, Montreal Neurological Institute.
Responsibilities include developing software to assist in the processing of proton magnetic resonance spectra and developing image analysis routines.
Summer 1995: Summer Student, McConnell Brain Imaging Center, Montreal Neurological Institute.
Participated in the development of software to perform automatic classification of brain tissue using magnetic resonance images.
June 1993-August 1994: Laboratory Assistant, Center for Neuronal Survival, Montreal Neurological Institute.
Prepared various chemical reagents, maintained laboratory apparata, conducted radioactivity checks.
Summer 1991, Summer 1992: Laboratory Assistant, Neuroimmunology Group, Montreal Neurological Institute.
Performed general laboratory assistance.
Summer 1989: Computer Assistant, Department of Oncology, Royal Victoria Hospital (Montreal, PQ).
Responsible for database entry and maintenance, software installation, bookkeeping.

Publications:

JOURNAL ARTICLES Bernasconi A, Bernasconi N, Natsume J, Antel SB, Andermann F, Arnold DL. "Magnetic resonance spectroscopy and imaging of the thalamus in idiopathic generalized epilepsy". Brain 2003:126.

Kuznetsov YE, Caramanos Z, Antel SB, Preul MC, Leblanc R, Villemure JG, Pokrupa R, Olivier A, Sadikot A, Arnold DL. "Proton magnetic spectroscopic imaging can predict length of survival in patients with a supratentorial glioma". Neurosurgery 2003: In press.

Antel SB, Collins DL, Bernasconi N, Andermann F, Shinghal R, Kearney RE, Arnold DL, Bernasconi A. "Automated detection of focal cortical dysplasia lesions using computational models of their MRI characteristics and texture analysis". NeuroImage 2003: In press.

Bernasconi N, Bernasconi A, Caramanos Z, Antel SB, Andermann F, Arnold DL. "Mesial temporal damage in temporal lobe epilepsy: a volumetric MRI study of the hippocampus, amygdala, and parahippocampal region". Brain 2003:126(2), 462-469.

 Antel SB, Bernasconi A, Bernasconi N, Collins DL, Kearney RE, Shinghal R, Arnold DL."Computational models of MRI characteristics of focal cortical dysplasia improve lesion detection". NeuroImage 2002:17(4), 1755-1760.

 

Tartaglia MC, Narayanan S, DeStefano N, Arnaoutelis R, Antel SB, Francis SJ, Santos AC, Lapierre Y, Arnold DL. "Choline is increased in pre-lesional normal appearing white matter in multiple sclerosis". Journal of Neurology 2002:249(19), 1382-1390.

 

Antel SB, Li LM, Cendes F, Collins DL, Kearney RE, Shinghal R, Arnold DL."Predicting surgical outcome in temporal lobe epilepsy patients using MRI and MRSI".Neurology 2002: 58(10),1505-1512.  

Cendes F, Knowlton RC, Novotny E, Li LM, Antel S, Sawrie S, Laxer KD, Arnold DL. "Magnetic resonance spectroscopy in epilepsy: clinical issues". Epilepsia 2002: 43(Suppl. 1),32-39.  

Bernasconi A, Antel SB, Collins DL, Bernasconi N, Olivier A, Dubeau F, Pike GB, Andermann F, Arnold DL. "Texture analysis and morphological processing of MRI assist detection of focal cortical dysplasia in extra-temporal partial epilepsy". Annals of Neurology 2001: 49(6),770-5.  

Serles W, Li LM, Antel SB, Cendes F, Gotman J, Olivier A, Andermann F, Dubeau F, Arnold DL. "Time course of postoperative recovery of N-acetyl-aspartate in temporal lobe epilepsy". Epilepsia 2001:42(2),190-7.  

Li LM, Caramanos Z, Cendes F, Andermann F, Antel SB, Dubeau F, Arnold DL. "Lateralization of temporal lobe epilepsy (TLE) and discrimination of TLE from extra-TLE using pattern analysis of magnetic resonance spectroscopic and volumetric data." Epilepsia 2000:41(7),832-842.  

Li LM, Cendes F, Antel SB, Andermann F, Serles W, Dubeau F, Olivier A, Arnold DL. "Prognostic value of proton magnetic resonance spectroscopic imaging for surgical outcome in patients with intractable temporal lobe epilepsy and bilateral hipppocampal atrophy". Annals of Neurology 2000:47(2), 195-200.
REVIEWED ABSTRACTS Antel SB, Bernasconi N, Andermann F, Bernasconi A. "Texture analysis lateralizes seizure focus in TLE patients with normal volumetric MRI". American Epilepsy Society 2003 annual meeting.

Kinay D, Bernasconi N, Antel SB, Khalili N, Dubeau F, Andermann F, Bernasconi A. "Hippocampal shape and positioning in malformations of cortical development and healthy subjects". American Epilepsy Society 2003 annual meeting.

Antel SB, Bernasconi N, Bernasconi A. "Texture analysis of mesial temporal lobe structures lateralizes seizure focus in TLE patients with volumetrically normal MRI". HBM 2003 annual meeting.

Antel SB, Bernasconi N, Collins DL, Kearney RE, Arnold DL, Bernasconi A. "Automated detection of focal cortical dysplasia based on textural, statistical and morphological analysis of MRI". ISMRM 2003 annual meeting.

Bernasconi N, Antel SB, Sankar T, Bernasconi A . "Quantitative assessement of temporopolar cortex and white matter in temporal lobe epilepsy using volumetric MRI and texture analysis". ISMRM 2003 annual meeting.

Bernasconi N, Antel SB, Bernasconi A . "Texture analysis in mesial temporal lobe epilepsy". ISMRM 2003 annual meeting.

Bernasconi N, Bernasconi A, Natsume J, Antel SB, Caramanos Z, Andermann F, Arnold DL. "MRI evidence for progressive structural damage in temporal lobe epilepsy". ISMRM 2003 annual meeting.

Bernasconi A, Bernasconi N, Natsume J, Antel SB, Andermann F, Arnold DL. "Magnetic resonance spectroscopy and imaging of the thalamus in idiopathic generalized epilepsy". ISMRM 2003 annual meeting.

Bernasconi A, Antel S, Bernasconi N, Collins LD, Andermann F, Arnold DL. "Computer-aided detection of focal cortical dysplasia on high-resolution MRI". American Epilepsy Society 2002 annual meeting.

Narayanan S, Francis SJ, Sled JG, Santos AC, Antel SB, Levesque I, Brass S, Lapierre Y, Sappey-Marinier DL, Pike GB, Arnold DL. "Assessment of axonal injury and demyelination in the cerebral normal-appearing white matter of patients with multiple sclerosis". ISMRM 2002 annual meeting.

Caramanos Z, Campbell JSW, Narayanan S, Antel SB, Reddy H, Matthews PM, Sappey-Marinier DL, Pike GB, Arnold DL. "Axonal integrity and fractional anisotropy in the normal-appearing white matter of patients with multiple sclerosis: relationship to cerebro-functional reorganization and clinical disability". ISMRM 2002 annual meeting.

Kuznetsov YE, Caramanos Z, Antel SB, LeBlanc R, Preul MC, Arnold DL. "Length of survival in patients with a supratentorial glioma is related to the MRI- and proton SIR spectroscopy (1H-MRSI)-defined spatial location of their tumor". American Association of Neurological Surgeons 2002 annual meeting.

Bernasconi A, Antel SB, Bernasconi N, Collins DL, Andermann F, Arnold DL. "Automatic detection of focal cortical dysplasia on magnetic resonance imaging". Epilepsia 2001: 42(Suppl. 7), p. 63.

Sappey-Marinier D, Antel SB, Tartaglia MC, Narayanan S, Francis SJ, Arbel T, Arnold DL. "Quantification metabolique dans la sclerose en plaques par imagerie spectroscopique RMN". Revue Neurologique, Suppl. 2001: 3(157), p. 2S145.

Tartaglia MC, Narayanan S, DeStefano N, Arnaoutelis R, Antel SB, Francis SJ, Santos AC, Lapierre Y, Arnold DL. "Choline is increased in pre-lesional normal appearing white matter in multiple sclerosis". American Academy of Neurology 2001 Meeting.

Antel SB, Li LM, Cendes F, Olivier A, Andermann F, Dubeau F, Kearney RE, Shinghal R, Arnold DL. "An MR-based Bayes classifier for the prediction of surgical outcome in temporal lobe epilepsy patients". Epilepsia 2000: 41(Suppl. 7), p. 164.

Bernasconi A, Antel SB, Collins DL, Bernasconi N, Dubeau F, Olivier A, Andermann F, Pike GB, Arnold DL. "MRI texture analysis improves detection of focal cortical dysplasia". Epilepsia 2000: 41(Suppl. 7), p. 82.

Bernasconi A, Antel SB, Bernasconi-Ladbon N, Collins DL, Arnold DL. "Texture analysis of MRI assists in the detection of focal cortical dysplasia lesions." Proc ISMRM, 2000.

Antel SB, Li LM, Cendes F, Olivier A, Andermann F, Dubeau F, Kearney RE, Shinghal R, Arnold DL. "Predicting surgical outcome in temporal lobe epilepsy patients using a naive Bayes classifier". Proc AIMDM Workshop on Prognostic Models in Medicine, 1999.

Li LM, Caramanos Z, Cendes F, Antel S, Andermann F, Dubeau F, Arnold DL. "Pattern analysis of data from 1H-MR spectroscopic imaging and MR volumetry of mesial temporal lobe structures predict results of prolonged video-EEG monitoring in temporal lobe epilepsy patients". Proc ISMRM, 1999.

Li LM, Cendes F, Antel S, Serles W, Andermann F, Dubeau F, Olivier A, Arnold DL. "Prognostic features in surgical outcome of patients with bilateral hippocampal atrophy and intractable temporal lobe epilepsy". Neurology, 52(6), 1999.

Serles W, Li LM, Cendes F, Gotman J, Antel S, Olivier A, Andermann F, Dubeau F, Arnold DL. "Time course of postoperative NAA recovery in patients with intractable temporal lobe epilepsy." Neurology, 52(6), 1999.

Antel S, Li LM, Arnold DL. "Automated baseline correction and metabolite peak measurement in brain 1H-MRSI using linear discriminant analysis". Proc ISMRM, p. 1844, 1998.

Li LM, Cendes F, Antel S, Dubeau F, Andermann F, Arnold DL. "Specificity of proton MR spectroscopy imaging in partial epilepsies". American Epilpesy Society, 1997.

Cousins JP, Antel S, Grigoropoulous J, Davenport C, Eames F, Wagle WA. "Clinical evaluation of HIV CNS lesions: differential of CNS lymphoma vs. toxoplasmosis and other HIV CNS complications". Proc ISMRM, p. 1134, 1997.

Cousins JP, Antel S, White LD, Kenney EA. "Classification and correlation of HIV-infection stage using MR spectroscopic data and neural networks". Proc RSNA, p.1608, 1996.

Cousins JP, Antel S, Seymour PA, Weaver S, Emrich J, Dollar J, King V, Herman M, Wagle WA. "Clinical evaluation of CNS tumors and radiation necrosis using single voxel H-1 MRS and linear discriminant analysis. MR of cancer physiology and metabolism". Proc ISMRM, 1996:48.

Invited Talks:

Third International Symposium on Magnetic Resonance in Epilepsy, Birmingham, Alabama, October 2000.

Conference Presentations:

American Epilepsy Society, Los Angeles, December 2000.

Joint European Conference on Artificial Intelligence in Medical Decision Making, Aalborg, Denmark, June 1999.

International Society of Magnetic Resonance in Medicine, 6th Annual Meeting, Sydney, Australia, April 1998.

Awards:

Young Investigator Award, American Epilepsy Society, 2000 Meeting

Computer skills:

Languages: C, MATLAB, Fortran, Pascal, Basic, HTML
Experienced with MINC routines and libraries.
Operating systems: Linux/UNIX, Windows

References:

Available upon request.

samson@mrs.mni.mcgill.ca

last updated March 11th, 2003