The simulation of PET images with PETSIMU [13] requires attenuation and emission coefficients to be associated with each tissue class of the phantom. PETSIMU produces images by generating line integrals through the phantom using the specific acquisition geometry and 3D detector response function of a multi-slice tomographic imaging system. Physical effects such as attenuation, scatter, randoms, detector efficiency and Poisson noise are also incorporated to generate realistic data (see Fig. 4b).
