Conclusion

The results indicate that subjects with a family history of language impairment combined with an impaired diagnosis on DST exhibit an increase in the cortical CSF/gray ratio; thus suggesting cortical atrophy. Since this phenomenon was observed in subjects with a family history of language impairment, we hypothesize that cortical atrophy in these subjects may be an inherited trait associated with single or multiple genes, the expression of which may lead to language impairment of specific type.