VERONIQUE BOHBOT, Ph.D.

Associate Professor, Department of Psychiatry
Associate Member, Department of Neurology and Neurosurgery
Faculty of Medicine, McGill University
Laboratory of Human Spatial Memory, Navigation and Functional Plasticity
Douglas Hospital Research Centre, FBC Building
6875 boul. LaSalle, Verdun, Quebec, Canada, H4H 1R3


Tucson, Arizona - where I obtained my Ph.D. with Dr. Lynn Nadel


Research

Our brains go through changes that are continuously renewing themselves as we experience the world. Research in my laboratory focuses on the multiple brain areas involved in processing episodic memories (spatio-temporal information) during navigation. We are interested in changes in the brain that occur as a result of practice or a learning experience. Multi-model aspects of memory, including visual, auditory, olfactory and proprioceptive aspects are being studied. Approaches include functional neuroimaging, neuroanatomy, neuropsychology, genetic and hormonal analyses with various populations that range from early development to senescence (patients with Epilepsy, Leukemia, Attention deficit hyperactivity disorder, Alzheimer's or Parkinson's disease). Applications are aimed at using multiple memory systems geared at rehabilitation techniques in patients with brain damage.

Projects and Techniques Available in my Laboratory


Example of a virtual environments created by Txomin viewed from the Unreal Editor

Examples of Virtual Environments created in my laboratory

Created by Txomin


Support


Students, Fellows and Staff


Alumni


Knowledge Transfer Activities

  • Walrus Global Impositioning Systems
  • MSNBC GPS Addict
  • French TV, General Lecture: Canal Savoir Ecole MiniPsy
  • French TV, Scientific Report: Tele Quebec Code Chastenay

    Publications

  • Ledoux, A. A., Phillips, J. L., Labelle, A., Smith, A., Bohbot, V. D., Boyer, P. (2013) Decreased fMRI activity in the hippocampus of patients with schizophrenia compared to healthy control participants, tested on a wayfinding task in a virtual town. Psychiatry Res. 211:47-56. (745KB)

  • Konishi, K., Bohbot, V. D. (2013) Spatial navigational strategies correlate with gray matter in the hippocampus of healthy older adults tested in a virtual maze. Front Aging Neurosci. 5:1. (3.7MB)

  • Bohbot, V. D., McKenzie, S., Konishi, K., Fouquet, C., Kurdi, V., Schachar, R., Boivin, M. & Robaey, P. (2012) Virtual navigation strategies from childhood to senescence: evidence for changes across the life span. Front Aging Neurosci. 4:28. (613KB)

  • Schwabe, L., Bohbot, V.D. and Wolf, O.T. (2012) Prenatal stress changes learning strategies in adulthood. Hippocampus. 11:2136-43 (1.5 MB)

  • Dahmani, L., Ledoux, A.-A., Boyer, P., & Bohbot, V.D. (2012) Wayfinding: The Effects of Large Displays and 3D Perception Behavioral Research Methods 44:447-54. (350KB)

  • Andersen, N., Dahmani, L., Konishi, K. & Bohbot, V.D. (2012) Sex Differences in Virtual Navigation from an eye tracking perspective. Neurobiology of Learning and Memory 97:81-9. (730KB)

  • Etchamendy, N., Konishi, K., Pike, B.G., Marighetto, A., & Bohbot, V.D. (2012) Evidence for a virtual human analog of a rodent relational memory task: a study of aging and fMRI in young adults Hippocampus 22:869-80. (600KB)

  • Bohbot, V.D., Gupta, M., & Banner, H., Dahmani, L. (2011) Caudate nucleus-dependent response strategies in a virtual navigation task are associated with lower basal cortisol and impaired episodic memory Neurobiology of Learning and Memory 96: 173-180. (400KB)

  • Banner, H., Bhat, V., Etchamendy, N., Joober, R., & Bohbot, V.D. (2011) The BDNF val66met polymorphism is associated with reduced fMRI activity in the hippocampus and increased use of caudate nucleus-dependent strategies in a human virtual navigation task. European Journal of Neuroscience 33: 968-977. (500KB)

  • Lerch, J.P, Yiu, A.P., Martinez-Canabal, A., Pekar, T., Bohbot, V.D., Frankland, P.W., Henkelman, R.M., Josselyn, S.A., & Sled, J.G. (2011) Maze training in mice induces MRI detectable brain shape changes specific to the type of learning. Neuroimage 54:2086-95. (2MB)

  • Taevs, M., Dahmani, L., Zatorre, R.J., & Bohbot, V.D. (2010) Semantic Elaboration in Auditory and Visual Spatial Memory Frontiers in Auditory Cognitive Neuroscience 1, article 228, pp 1-10. (1MB)

  • Bohbot, V.D., Lerch, J., Thorndycraft, B., Iaria, G. & Zijdenbos, A. (2007) Gray matter differences correlate with spontaneous strategies in a human virtual navigation task. Journal of Neuroscience 27, 10078-10083. (200KB)

  • Bohbot, V.D. and Corkin, S. (2007) Parahippocampal place learning in H.M. Hippocampus, 17: 863-872. (300KB)

  • Etchamendy, N. and Bohbot, V.D. (2007) Spontaneous navigational strategies and performance in the virtual town. Hippocampus, 17: 595-599. (250KB)

  • Hupbach, A., Hardt, O., Nadel, L., and Bohbot, V. D. (2007) Spatial reorientation: Effects of verbal and spatial shadowing. Spatial Cognition & Computation 7: 213-226. (1,000KB)

  • Bohbot, V.D., Iaria, G., Petrides, M. (2004) Hippocampal function and spatial memory: Evidence from functional neuroimaging in healthy participants and performance of patients with medial temporal lobe resections. Neuropsychology 18(3):418-425. (200KB)

  • Stepankova K., Fenton A.A., Pastalkova E., Kalina M., Bohbot V.D. (2004) Object location memory impairment in patients with thermal lesions to the right or left hippocampus. Neuropsychologia, 42 (8): 1017-1028. (350KB)

  • Iaria, G., Petrides, M., Dagher, A., Pike, B., and Bohbot, V.D. (2003) Cognitive Strategies Dependent on the Hippocampus and Caudate Nucleus in Human Navigation: Variability and Change with Practice. J. Neuroscience, 23(13):5945-5952. (350KB)

  • Bohbot, V.D., Jech, R., Ruzicka, E., Nadel, L., Kalina, M., Stepankova, K. and Bures, J. (2002). Rat spatial memory tasks adapted for humans: characterization in subjects with intact brain and subjects with medial temporal lobe lesions. Physiological Research, 51 Suppl 1:S49-64. (716KB)

  • Nadel, L. and Bohbot, V.D. (2001) Consolidation of memory. Hippocampus, 11:56-60. (209KB)

  • Bohbot, V.D., Allen, J.J.B., and Nadel, L. (2000) Memory deficits characterized by patterns of lesions to the hippocampus and parahippocampal cortex. Annals of the New York Academy of Sciences, 911: 355-368. (6.4MB)

  • Johnsrude, I.S., Owen, A.M., White, N.M. Zhao, V.W., and Bohbot, V.D. (2000) Impaired preference conditioning after anterior temporal lobe resection in humans. Journal of Neuroscience, 20(7):2649-2656. (1 MB)

  • Bohbot, V.D., Kalina, M., Stepankova, K., Spackova, N., Petrides, and Nadel, L. (1998) Spatial memory deficits in patients with lesions to the right hippocampus and to the right parahippocampal cortex. Neuropsychologia, 36: 1217-1238. (23 MB)

  • Bohbot, V.D., Jech, R., Bures, J., Nadel, L., and Ruzicka, E. (1997) Spatial and non-spatial memory involvement in myasthenia gravis. Journal of Neurology, 244: 529-532. (1 MB)

  • Bohbot, V., Otahal, P., Liu, Z., Nadel, L., and Bures, J. (1996). Electroconvulsive shock and lidocaine reveal rapid consolidation of spatial working memory in the water maze. Proceedings of the National Academy of Sciences, 93: 4016-4019. (235 KB).


    Selected Posters & Data

  • Modulation of fMRI activation in hippocampus by spatial memory tested on a virtual radial-maze (343 KB). Society for Neuroscience Abstracts 2002, 475.10.

  • The collateral sulcus as a landmark for the parahippocampal cortex (page 1 of 2, 1.9 MB). NeuroImage.

  • The collateral sulcus as a landmark for the parahippocampal cortex (page 2 of 2, 1.9 MB). NeuroImage.

  • Verbal Reports. Bohbot et al., (2007) Journal of Neuroscience.
    E-mail:
    <veronique.bohbot@mcgill.ca>
    Office phone:
    (514) 761-6131, ext 4408
    Lab phone:
    (514) 761-6131, ext 3408
    Office fax:
    (514) 888-4099

    Links


    2012 Society for Neuroscience Memory Systems Symposium

    Title: Independence and interaction of multiple memory systems

    Description: The purpose of this symposium is to integrate recent findings regarding the extent to which the medial temporal lobe system is independent of, or interactive with, other brain regions specialized for memory processing and storage. Brain regions that have been investigated extensively for their roles in memory include the medial temporal lobe, neostriatum, amygdala, and neocortex. The multiple memory systems hypothesis was supported initially by reports of dissociations among brain regions specialized for acquisition and storage of various types of information. While dissociations suggest independence among systems, there is also evidence that memory systems may be interactive during either memory formation or retrieval. Reports of interactions suggest that memory systems may be cooperative, competitive, or operate in temporal sequence. This symposium will bring together researchers who study multiple memory systems in human and non-human animal models at behavioral and physiological levels using genetic, electrophysiological, pharmacological, or fMRI methodologies. The goal will be to elucidate conditions under which brain regions operate independently or interactively during memory formation and retrieval. Moreover, for conditions in which memory systems are interactive, we will work toward an explanation of cooperation and competition.

  • Find Program Information and Register for the 2012 SfN Symposium held on October 12, 2012 in New Orleans *** REGISTRATION IS FREE BUT REQUIRED BY SEPT 15 (Coffee and Lunch Provided) *** (click here)
    VERO <veronique.bohbot@mcgill.ca>
    last updated: 30 July 2012