Research

 

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I'm currently finishing my PhD program in neuropsychology at McGill and the Montreal Neurological Institute under the supervision of Dr. Robert Zatorre.  My main research interest is investigating what goes on in our brains that makes us able to decode, appreciate, and enjoy the sounds that make up a musical experience.  My thesis focuses on the neural correlates of pitch perception, and how that perception can change within a tonal context.  I've listed my research presentations and brief descriptions of my research projects below, along with links to McGill, the Montreal Neurological Institute, and the McConnell Brain Imaging Centre, and other academic links.

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McGill University Montreal Neurological Institute McConnell Brain Imaging  Centre (BIC)

 

Research Presentations:

1996 - Warrier, C., & Zatorre, R. (1996).  The Effect of Melodic Context on Interactions Between Pitch and Timbre.  Paper presented at the 4th International Conference on Music Perception and Cognition, Montreal, Quebec. 
1998 - Warrier, C.M., Zatorre, R.J., Peretz, I., Besson, M., & Evans, A.C. (1998, June). PET Study Investigating the Separation of Lyrics and Music in Song.  Poster presented at the 4th International Conference on Functional Mapping of the Human Brain, Montreal, Quebec.
1998 - Zatorre, R.J., Bermudez, P., Warrier, C.M., & Evans, A.C. (1998, June). Cerebral Mechanisms Associated with Encoding and Recognition of Melodies.  Poster presented at the 4th International Conference on Functional Mapping of the Human Brain, Montreal, Quebec.
1999 - Warrier, C.M., & Zatorre, R.J. (1999, August). The Role of Right Temporal Cortex in Effects of Melodic Context. Paper presented at the Society for Music Perception and Cognition, held at Northwestern University, Evanston, Illinois
1999 - Warrier, C.M., Belin, P., Merlet, I., and Zatorre, R.J. (1999, October). fMRI study title. Poster presented at the Society for Neuroscience conference, Miami, Florida.


Research Projects:

Psychophysical Behavioral Study (presented at ICMPC ’96, submitted for publication): 

Catherine Warrier, Dr. Robert Zatorre

Tested undergraduates’ ability to make pitch discriminations while ignoring interfering timbral changes.  The same test tones were presented in different contexts: melodic, non-melodic tone series, and two-tones only.  We found that although timbre interfered with pitch judgments in all conditions, people were more able to ignore this interference in the tone-series condition than in the two-tone condition, and even more so in the melodic condition.

 Patient Study (presented at SMPC '99):

Catherine Warrier, Dr. Robert Zatorre

Tested patients who have had surgical excisions within their temporal lobes for treatment of intractable seizures due to epilepsy on the same tests as described in the psychophysical behavioral study.  When the  patients’ excisions included right secondary auditory cortex, they not only had more difficulty in general with the task, but they were not able to use the facilitating cues of the melodic context to the same extent as the control group.   

ERP / fMRI Study (ongoing):

Catherine Warrier, Dr. Isabelle Merlet, Dr. Pascal Belin, Dr. Robert Zatorre, Dr. Jean Gotman

When and where is the facilitatory effect of melodic context on pitch discrimination occurring in the normal brain?  The timing accuracy of EEG is perfect for addressing the “when” part of this question.  Participants discriminated the pitches of the last two notes of a melody, random tone series, or two-tone pair while hooked up to the EEG.  We will be comparing the resulting evoked potential (EP) waveforms of each condition and analyzing when and how they begin to differ.  This will be complemented by a dipole analysis of the same data.  We will be running the same subjects on the same tasks with an event-related fMRI protocol shortly.  This will enable us to compare areas of increased BOLD signal between conditions, as well as provide an objective way of constraining the inverse problem of dipole modeling of the EP’s.   We will co-register the individual anatomical scans to both the fMRI and dipole analysis data for ease of interpretation.

 

PET Study (presented at Human Brain Mapping ‘98):

Catherine Warrier, Dr. Robert Zatorre, Dr. Isabelle Peretz, Dr. Mireille Besson. Dr. Alan Evans

This study investigated the separation of lyrics and melody in song.   Francophone musicians listened to short excerpts of French opera sung a capella and decided if the last note was sung correctly, out of tune, and/or with the wrong word.  During each scan they were instructed to pay attention to either the melody or the lyrics.  Due to the complex auditory stimuli, all scans showed a large increase in cerebral blood flow (CBF) to the superior temporal gyrus bilaterally.  When attending to the lyrics, left inferior frontal areas were included in the pattern of activation.  When attending to the melody, a different although less consistent pattern was observed, indicating that lyrics and melody are processed separately in the brain.


Academic links:


Universities (see also my schools page):

McGill University

Northwestern University

University of Illinois

 

Neuro-related sites:

Dr Robert Zatorre's Lab

Neurosciences on the Internet

Cajal Medical and Scientific Illustration

UW Histology Atlas

 

Journals:

Psychonomic Society Publications

MIT Press Journals

 

Miscellaneous:

APA style guide from the University of Illinois

Merriam-Webster Dictionary

Auditory Demonstrations

 

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