MR Corticometry

• surface area of the PS of a single brain: between 200,000 and 248,000mm2, so whole-brain manual segmentation is difficult;

• automated methods:

  • edge detection: the "bottom-up" approach
  • model-based deformable surfaces techniques: e.g. ASP (developed at MNI), later upgraded to reduce partial-volume effects and better handle thicker cortices (now called CLASP). The generated surfaces are polygonal meshes 40,962 vertices each, allowing a vertex-based approach to corticometry