Objective overview

The NIH MRI Pediatric Study of Normal Brain Development has two main objectives and two ancillary objectives:

• Objective 1

Anatomic MRI and cognitive/behavioral cross-sectional and longitudinal studies of children between the ages 4 years, 6 months and 18 years, 3 months (at time of first scan).

• Objective 2

Anatomic MRI and cognitive/behavioral cross-sectional and longitudinal studies of children between the age of newborn and 4 years, 5 months (at time of first scan).

• Ancillary A

MR Spectroscopy (MRS) of children between the ages of newborn (10-14 days) and 18 years, 3 months (at time of first scan).

• Ancillary B

Diffusion Tensor Imaging (DTI) of children between the ages of newborn (10-14 days) and 4 years, 5 months (at time of first scan). However this was broadened to include subjects of all ages. An expanded DTI (eDTI) protocol was developed and acquisitions began in the spring of 2006.