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| Volumetric MRI of Limbic Areas in Temporal Lobe Epilepsy | |||
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| Conventional MRI of Focal Cortical Dysplasia | Multiplanar Curvilinear Reformatting in Focal Cortical Dysplasia | ||
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| Computer Models of Focal Cortical Dysplasia | |||
| Human epileptogenesis is a complex functional process and its anatomical basis is poorly understood. Advanced MR imaging techniques have great potential to improve our understanding of the basic mechanisms of epilepsy. |
| MRI has had a major impact in epilepsy surgery by helping defining cerebral structural damage and consequently in delineating the extent of the epileptogenic zone, i.e. the site of seizure onset. The detection of a lesion has important prognostic implications with respect to seizure outcome after surgery. However, reliable lesion detection is often not possible based on conventional MRI analysis. This clinical requirement gave us the motivation to develop advanced image analysis methods in our imaging laboratory. |
| To assess brain pathology in various forms of epilepsy, we apply several advanced image acquisition techniques such as high-resolution anatomical MRI, volumetric MRI, T2-relaxometry, MR spectroscopy and diffusion MRI. We also applied image analysis methods such as volumetric MRI, voxel-based morphometry and shape analysis, and implemented original methods based on texture analysis. |
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Temporal Lobe Epilepsy In temporal lobe epilepsy (TLE), most attention has been paid to study of the hippocampus, which is thought to play the main role in the genesis of epileptic seizures. However, there is evidence suggesting that the epileptogenic zone in TLE is broad, and indicating that the substrate for seizure generation is distributed over several brain areas. We believe that broadening the MRI assessment to include these areas will provide a more complete view of the structural and functional changes associated with TLE. Click here for publications |
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Extra-temporal Lobe Epilepsy Malformations of cortical development (MCD) are increasingly recognized as an important cause of intractable extra-temporal epilepsy. However, the number of cases treated surgically is far less and the prognosis poorer than patients operated for other types of lesions. This is due to the fact that identification of many of these malformations on visual inspection of conventional MRI is difficult due to their subtlety and the complexity of the brain's convolution. Our research in this area is focused on improving detection of subtle MCD lesions using novel MR based methods. This research also aspires to further our understanding brain structure and function in MCD. Click here for publications |
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| Volumetric MRI of Limbic Areas in Temporal Lobe Epilepsy | |||
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| Conventional MRI of Focal Cortical Dysplasia | Multiplanar Curvilinear Reformatting in Focal Cortical Dysplasia | ||
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| Computer Models of Focal Cortical Dysplasia | |||