NIHPD Objective 1 atlas (4.5–18.5y)

Overview

Attach:NIHPD-obj1.png We present an unbiased standard magnetic resonance imaging template brain volume for pediatric data from the 4.5 to 18.5y age range.

These volumes were created using data from the NIH-funded MRI study of normal brain development.

Tools for registering a native MRI to the MNI macaque atlas can be found in the Software section.

Viewing

Viewing the multiple atlas volumes online requires Java browser support. The Java Internet Viewer (JIV2) used here is available for download and personal use under the GNU general public license (GPL).

atlases will be available for viewing after the submitted NeuroImaging article.

The MNI stereotaxic coordinates (X,Y,Z) are displayed in the first row below the volumes.

For viewing, one can use the left most mouse button to click on any image, and the other cross-sectional images will be updated with the appropriate position. You can also hold the middle/rocker mouse button down while moving up or down, to pan through the image plane. Holding ‘Shift’ with the left or middle button will enable dragging and zooming.

When looking at the images, remember that left is left and right is right!

Methods

The pediatric average atlases are comprised of….

Image pre-processing included non-uniform intensity correction and intensity normalization with a range of 0–100. next steps…

The ANIMAL algorithm (Collins et al., 1995) was used to estimate the nonlinear deformation field that best aligned local neighbourhoods between each monkey volume and the average target. The nonlinear registration began by estimating a grid with 3mm spacing. Each MRI volume was resampled through the recovered nonlinear transformation, and all resampled volumes were averaged together on a voxel-by-voxel basis to create a mean intensity image. To remove the potential bias of the initial atlas used for registration, all deformation fields were average together and then the average deformation was inverted and then applied to the mean intensity volume to create a spatially unbiased, average intensity atlas volume that is used as the target for the next registration step. This process was repeated twice, using a grid spacing of 2mm, and then 1mm.

Publications

The following publications should be referenced when using this atlas:

VS Fonov, AC Evans, RC McKinstry, CR Almli and DL Collins Unbiased nonlinear average age-appropriate brain templates from birth to adulthood NeuroImage, Volume 47, Supplement 1, July 2009, Page S102 Organization for Human Brain Mapping 2009 Annual Meeting

Download

Click here to download the atlas and associated files in your chosen format.

Contact

For questions related to the MNI NIHPD atlases (rather than the website), contact Vladimir Fonov