Q: Hi there, I just wanted to see if anyone remembers the HBM abstract that Bruce is referring to here regarding cortical thickness normalization. Does anyone have a different opinion on this matter? Thanks in advance for your time.
http://www.bic.mni.mcgill.ca/pipermail/minc-users/2008-January/001881.html

A: that was an abstract first-authored by Yasser Ad-Dab’bagh, and I indeed believe that the main conclusion still holds. (I can send you the PDF of the abstract if you like). There is no relationship between the thickness of the cortex and overall brain size- normalization thus artificially distorts the thickness rather than compensating for a simple scaling factor.

This argument even extends across evolution - compare the thickness of the mouse cortex, which is around 0.9mm, or about 3 times smaller than human cortical thickness, to the difference in overall brain volume (several orders of magnitude).