Q: Hi All, I’m currently doing some cortical thickness regressions, and would like to include a measure of intracranial volume as a covariate. Now, I know that I can get a measure of brain volume using either the Civet (native) brain mask, or by summing the tissue classification components (CSF,GM,WM), however, brain volume does not include the volume of CSF located between the cortical surface and the inner aspect of the skull. For a normal, young population, these measures may be effectively the same, but for elderly and demented, they are not. Any ideas?
http://www.bic.mni.mcgill.ca/pipermail/minc-users/2008-November/002275.html

A: Speak to Louis. He has the code to compute intracranial capacity (ICC) as part of his BICCR (Brain to ICC Ratio) measure of normalized brain volume. If you have a PD-weighted scan as part of your acquisition, you should be in business.