Q:Hi all, I would like to perform a voxel-based morphometry analysis on my anatomical MRI data, adopting the “optimized” VBM procedure (i.e. with the iterative process of segmentation and normalization which should allow for a better voxel classification, as described in Good et al., 2001). However, on the BIC’s wikipages (even on the page entitled “VBM optimized”) I only see the guidelines for the “standard” VBM (i.e. normalize THEN segment).

Could anybody tell me if it is possible to perform the optimized VBM using our local software?
http://www.bic.mni.mcgill.ca/pipermail/minc-users/2008-January/001876.html

A: A while back I also searched for a way to do the optimized vbm at the BIC but ended up using SPM since the “optimized” concept was already implemented in the SPM5 pipeline.

However, if it is of any interest, the additional modulation step (multiplication of tissue class by the relative volumes before and after warping) can be done using the existing BIC tools.