Kangjoo Lee, Ph.D. Candidate

kangjoo

She received her BS degree in Radiological Science from Yonsei University in 2009, supervised by Dr. Yong Hyun Chung in Molecular Imaging Laboratory. Then she pursued her graduate studies in the laboratory of Bio-Imaging and Signal Processing under Dr. Jong Chul Ye and obtained her MS degree in Bio and Brain Engineering from Korea Advanced Institute of Science and Technology (KAIST) in 2011. After working as a post-MS researcher in KAIST, she started working as a post-MS researcher in Neuroscience Research Institute at Gachon Univ. of Medicine and Science from September 2011. She has been a Ph.D. student in MultiFunkIm laboratory (Department of Biomedical Engineering) and Montreal Neurological Institute since September 2012, as she is enrolled in the Integrated Program in Neuroscience in McGill University.

  • Supervisor: Christophe Grova Ph.D.
  • Co-supervisor: Jean Gotman Ph.D.

Contact Info

Research Interests

My current research focuses on multimodal functional connectivity (FC) characterizing resting-state (RS) fMRI data in normal and pathological conditions in epilepsy. We recently developed a sparse dictionary learning based FC hub analysis using RS fMRI data, where statistical reproducibility at the individual level can be achieved by a bootstrap resampling based strategy (Published in 2016). Using the method, entitled as SPARK, we found a significant reorganization of FC connector hubs (disruption, emergence and lateralization) in patients with mesial temporal lobe epilepsy (Published in 2018). We also developed an automatic classification and removal of structured physiological noise for FC analysis using fMRI (Published in 2019). Currently, we are investigating (i) the reorganization of FC hubs at different vigilance states (e.g. wakefulness and sleep), (ii) the relationship between the brain metabolism and functional connector hubs in healthy subjects and in focal epilepsy and (iii) the relation between MEG resting state connectivity, fMRI hubs, and seizure outcome in epilepsy surgery.

Publications

Journal Articles

Kangjoo Lee, Hui Ming Khoo, Constance Fourcade, Jean Gotman and Christophe Grova, “Automatic classification and removal of structured physiological noise for resting state functional connectivity MRI analysis”, Magnetic Resonance Imaging, vol. 58, pp. 97–107, January 2019

Kangjoo Lee, Hui Ming Khoo, Jean-Marc Lina, François Dubeau, Jean Gotman and Christophe Grova, “Disruption, emergence and lateralization of brain network hubs in mesial temporal lobe epilepsy”, Neuroimage: Clinical, vol. 20, pp. 71–84, June 2018

Kangjoo Lee, Jean-Marc Lina, Jean Gotman and Christophe Grova, “SPARK: Sparsity-based analysis of reliable k-hubness and overlapping network structure in brain functional connectivity”, Neuroimage, vol. 134, pp. 434–449, April 2016

Young-Beom Lee, Jeonghyeon Lee, Sungho Tak, Kangjoo Lee, Duk L. Na, Sangwon Seo, Yong Jeong, Jong Chul Ye, and The Alzheimer’s Disease Neuroimaging Initiative, “Sparse SPM: Group Sparse-dictionary learning in SPM framework for resting-state functional connectivity MRI analysis”, Neuroimage, vol. 125, pp. 1032–1045, January 2016

Christian Dansereau, Pierre Bellec, Kangjoo Lee, Francesca Pittau, Jean Gotman and Christophe Grova (2014). “Detection of abnormal resting-state networks in individual patients suffering from focal epilepsy: An initial step toward individual connectivity assessment”. Front. Neurotic. 8:419. doi: 10.3389/fnins.2014.00419

Kangjoo Lee, Sungho Tak, and Jong Chul Ye, “A data-driven sparse GLM for fMRI analysis using sparse dictionary learning with MDL criterion”, IEEE Trans. Med. Imag., vol. 30, no. 5, pp. 1076–1089, May 2011

Sungho Tak, Jaeduck Jang, Kangjoo Lee and Jong Chul Ye, “Quantification of CMRO2 without hypercapnia using simultaneous near-infrared spectroscopy and fMRI measurements,”, Physics in Medicine and Biology, vol. 55, pp. 3249–3269, May 2010

Yong Hyun Chung, Seung-Jae Lee, Cheol-Ha Baek, Kang-Joo Lee, and Yong Choi, “Characterization and optimization of a quasi-monolithic detector module with depth-encoding for small animal PET”, J. Korean Phys. Soc., vol. 54, no. 1, pp. 244–249, January 2009

Conference Presentations

Kangjoo Lee, Aude Jegou, Florence B. Pomares, Nathan Cross, Aurore A. Perrault, Alex Nguyen, Umit Aydin, Jean Gotman, Thien Thanh Dang-Vu and Christophe Grova, “Reorganization of functional hubs during non-rapid eye movement sleep after sleep deprivation”, The 25th Annual Meeting of the Organization for Human Brain Mapping (OHBM), June 2019, Rome, Italy (Poster session)

Fatemeh Razavipour, Kangjoo Lee, Stephane Blinder, Jean-Paul Soucy, Claudine J. Gauthier, and Christophe Grova, “Oxygen and glucose metabolism in connector hubs estimated from resting-state fMRI”, International Society of Magnetic Resonance in Medicine (ISMRM), May 2019, Montreal, Canada, (E-poster session)

Ümit Aydin, Kangjoo Lee, Giovanni Pellegrino, Obaï Bin Ka’b Ali, Jean-Marc Lina, François Dubeau, Eliane Kobayashi, Jean Gotman, Christophe Grova, “Investigating the relation between MEG resting state connectivity, fMRI hubs, and seizure outcome in epilepsy surgery”, 2018 American Epilepsy Society (AES) Annual Meeting, December 2018, New Orleans, USA (Oral and poster sessions)

Fatemeh Razavipour, Kangjoo Lee, Claudine Joëlle Gauthier, Christophe Grova, “Analysis of oxygen metabolism within connector hubs estimated from resting-state fMRI”, Resting-State and Brain Connectivity 2018, Montreal, Canada (Poster session)

Kangjoo Lee, Hui Ming Khoo, Jean-Marc Lina, Francois Dubeau, Jean Gotman and Christophe Grova, “Identification of epileptic networks involving connector hubs in mesial temporal lobe epilepsy”, The 24th Annual Meeting of the Organization for Human Brain Mapping (OHBM), June 2018, Singapore (Poster session)

Kangjoo Lee, Hui Ming Khoo, Jean-Marc Lina, Jean Gotman and Christophe Grova, “Resting state fMRI reveals abnormal reorganization of network hubs in mesial temporal lobe epilepsy”, The 70th American Epilepsy Society (AES) Annual Meeting, December 2016, Houston, USA (Poster session)

Kangjoo Lee, Hui Ming Khoo, Jean Gotman and Christophe Grova, “Reorganization of Functional Hubs and Overlapping Networks in Mesial Temporal Lobe Epilepsy”, The 22th Annual Meeting of the Organization for Human Brain Mapping (OHBM), June 2016, Geneva, Switzerland (Poster session)

Kangjoo Lee, Hui Ming Khoo, Jean-Marc Lina, Jean Gotman and Christophe Grova, “Detection of functional hubs from resting state fMRI data and their reorganization in Mesial Temporal Lobe Epilepsy”, The 3rd Whistler Scientific Workshop on Brain Functional Organization, Connectivity and Behavior, March 2016, Whistler-Blackcomb, B.C., Canada (Accepted, Oral session)

Kangjoo Lee, Jean-Marc Lina, Jean Gotman, Christophe Grova, “Reliable Detection of Functional Connector Hubs and Overlapping Network Structure in Resting-State fMRI using SPARK”, Biological & Biomedical Engineering Symposium, September 2015, Montreal, Canada (First Place Winner, Poster Competition 2)

Kangjoo Lee, Jean-Marc Lina, Jean Gotman, Christophe Grova, “Organization of Functional Hubs in Healthy Human Brain”, The 2nd Annual PERFORM Centre Research Conference, May 2015, Montreal, Canada (Winner of the best poster presentation)

Kangjoo Lee, Jean-Marc Lina, Jean Gotman, Christophe Grova, “SPARK: Sparsity-based Analysis for Reliable k-hubness in brain functional connectivity”, The 20th Annual Meeting of the Organization for Human Brain Mapping (OHBM), June 2014, Hamburg, Germany (Poster session)

Christophe Grova, Christian L Dansereau, Pierre Bellec, Kangjoo Lee,Francesca Pittau, Jean Gotman, “Detection of Abnormal resting-state Networks in Individuals (DANI): application in epilepsy”, The 2nd Whistler Scientific Workshop on Brain Functional Organization, Connectivity and Behavior, March 2014, Whistler-Blackcomb, B.C., Canada (Oral session)

Kangjoo Lee, Jean-Marc Lina, Jean Gotman, Christophe Grova, “Characterization of stability in sparse brain network for resting-state fMRI”, Workshop on Scale-free Dynamics and Networks in Neuroscience, October 2013, Montreal, Canada (Poster session)

Kangjoo Lee, Jean Gotman, Christophe Grova, “Bootstrap analysis of stability in sparse dictionary learning for resting-state fcMRI”, The 19th Annual Meeting of the Organization for Human Brain Mapping (OHBM), June 2013, Seattle, United States (Poster session)