Christophe Grova Lab.: Multimodal Functional Imaging Lab (Multi FunkIm)

The Multimodal Functional Imaging Laboratory, directed by Pr. Christophe Grova, is a multidisciplinary team composed of neurologists and methodologists. The laboratory is actually based on two sites:
(i) Biomedical Engineering Dpt and part of the epilepsy group of the Montreal Neurological Institute, McGill University
(ii) Physics Dpt and PERFORM centre, Concordia University

We investigate multimodal data fusion to characterize brain mechanisms and especially epileptic activity. Our research project aims at developing methods to appropriately combine multimodal data in order to detect additional information that could be missed by considering each modality individually. A typical challenge is to combine modalities directly measuring neuronal activity with high temporal resolution with other modalities indirectly measuring the same function with high spatial resolution, through hemodynamic processes for instance. The project will involve the integration of three promising functional modalities:

  1. Simultaneous ElectroEncephaloGraphy (EEG) - MagnetoEncephaloGraphy (MEG) acquisitions, measuring directly on the scalp electric and magnetic components of signals generated by neurons synchronously active (at a ms scale).
  2. Simultaneous EEG - functional Magnetic Resonance Imaging (fMRI) acquisitions to measure, within the whole brain at a second scale, hemodynamic responses that correlate with signals detected on scalp EEG.
  3. Simultaneous EEG - Near InfraRed Spectroscopy (NIRS) acquisitions to measure local changes in oxy- and deoxy-hemoglobin at the time of signals detected on scalp EEG, by exploiting absorption properties of infrared light within brain tissues using optic fibres placed on the surface of the head. Note that our EEG/NIRS laboratory is located in Biomedical Engineering dpt and easily accessible from the McConnell Brain Imaging Centre.

The principal clinical application of this project will be to combine these three modalities using multimodal data fusion techniques to characterize brain regions involved during epileptic activity.
From MEG data acquisition to source localizationComplete multimodal investigation involving MEG source localization,
fMRI response and intra-cranial EEG investigation

You can learn more about my research interests, members in my lab, the EEG/NIRS Laboratory, my recent publications, or news.

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Latest Research Highlight

Brain Entropy in space and time (BEst)

Click here to get our “Brain Entropy in space and time (BEst)” plug-in in Brainstorm software: BrainEntropy
Please check our Brainstorm Tutorial describing the package


McGill University Biomedical EngineeringMontreal Neurological InstituteConcordia University Physics DepartmentConcordia University PERFORM Centre