Christophe Grova, PhD


Associate Professor in Physics Dpt and PERFORM centre, Concordia University
Adjunct Professor in Biomedical Engineering Dpt and Neurology and Neurosurgery Dpt, McGill University
Montreal Neurological Institute
Centre de Recherches en Mathématiques

Christophe Grova was born in Créhange (France) in 1974. In 1998, he received both the Engineering degree and the Master degree in biomedical engineering from the University of Technology of Compiègne, France, with a specialization in image and signal processing. From 1998 to 2002, he joined the IDM laboratory (UPRES 3192, University of Rennes 1, France), where he obtained a Ph.D. in “Validation of SPECT/MRI registration methods in the context of epilepsy”. Since January 2003, he has been working with the team of Jean Gotman at the Montreal Neurological Institute as a postdoctoral fellow. Since April 2006, he has been working also at the MagnetoEncephaloGraphy (MEG) centre of Université de Montréal (CERNEC) with Pierre Jolicoeur and Franco Lepore.

Being affiliated to both Biomedical Engineering and Neurology and Neurosurgery Departments since July 2008, Dr. Grova investigates the integration of multimodal functional data to study brain mechanisms at the time of epileptic activity. His research project aims at combining multimodal data in order to detect additional information that could be missed by considering each modality individually. His project involves the integration of three promising functional modalities:

(1) Simultaneous ElectroEncephaloGraphy (EEG) - MagnetoEncephaloGraphy (MEG) acquisitions, measuring directly on the scalp electric and magnetic components of epileptic signals generated by neurons synchronously active (at a ms scale). Source localization procedure is then required to localize the generators of these discharges within the brain.

(2) Simultaneous EEG - functional Magnetic Resonance Imaging fMRI acquisitions to measure, within the whole brain at a second scale, hemodynamic responses that correlate with epileptic discharges detected on scalp EEG.

(3) Simultaneous EEG - Near InfraRed Spectroscopy (NIRS) acquisitions to measure local changes in oxy- and deoxy-hemoglobin at the time of epileptic discharges detected on scalp EEG, by exploiting absorption properties of infrared light within brain tissues using optic fibres placed on the surface of the head.

The comparison of EEG/fMRI and EEG/NIRS offers a unique way to address in vivo the question of the integrity of the neurovascular coupling in the epileptic brain. In addition of studying brain mechanisms at the time of epileptic discharges, Dr. Grova is currently applying similar methodologies to study resting state functional connectivity in epilepsy patients.

Since July 2014, Christophe Grova became assistant Professor in Physics Dpt and researcher in the brand new multimodal imaging platform of PERFORM centre, while remaining adjunct Professor in Biomedical Engineering Dpt and Neurology and Neurosurgery Dpt of McGill University. This new imaging platform of PERFORM is equipped with a 3T MRI, simultaneous SPECT/CT and PET/CT devices, TMS and high density MR compatible EEG. His research projects are about to evolve to incorporate these new modalities, in order to study epileptic activity, but also many other applications in neurosciences including healthy aging, exercise and multimodal analysis of resting state functional connectivity.

Biomedical Engineering Department - Room 304 McGill University
3775 University Street, Montreal, Quebec, Canada, H3A 2B4
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