Contents

• List of Figures
• List of Tables
• Acknowledgments
• Abstract
• Résumé
• Contributions
• List of Symbols and Abbreviations
• Introduction
  • Conventional Stereotaxy
  • Image-Guided Neurosurgery
  • Image-Guidance System used at MNI
    • The Allegro workstation
    • The Viewing Wand
    • The FARO Surgical Arm
    • Pre-surgical preparation of an procedure
  • Accuracy
• Overview of Image-Guided Neurosurgery
  • Spaces Involved
    • Physical space
    • Model Space
    • Scanner Space
    • Surgical Space
  • Measurement in scanner space
    • Image acquisition
    • MR Geometrical Distortions
    • Reformatting
    • Rendering
      • 2-D
      • 3-D
  • Registration
    • Homologous point matching
    • Surface Matching
  • Accuracy of CT based
• Registration
  • Registration Error
  • Comparison between two registrations
  • Expectation of registration error
  • Homologous point matching simulations
  • Registration comparison in the clinical situation
  • Comparison between individual frame-based registrations
• Accuracy of localizing devices
  • Experimental Setup
  • Experimental Protocol
  • Data Analysis
    • Conversion of OPTOTRAK Data
    • Conversion of FARO Arm Data
    • Relative Accuracy Comparison
  • Results
  • Conclusion
• MR geometrical distortion
  • Distortion of Stereotactic Markers
    • Data acquisition
    • Data analysis
      • Fitting channels to straight lines
      • Intersection of two channels
    • Results
    • Conclusion
  • Field Mapping
    • Three-point Dixon technique
      • Three-Point-Dixon using gradient-echo
    • Results
    • Conclusion
• Conclusion and Future work
  • Future Work
    • Characterization of absolute registration error
    • Use of a localizer
    • Optimization of MR pulse sequences
    • Real time monitoring of anatomical changes
• References
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